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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TK1 All Species: 34.55
Human Site: T127 Identified Species: 84.44
UniProt: P04183 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P04183 NP_003249.3 234 25469 T127 I V A A L D G T F Q R K P F G
Chimpanzee Pan troglodytes XP_001145198 309 32942 T169 I V A A L D G T F Q R K P F G
Rhesus Macaque Macaca mulatta XP_001107944 234 25438 T127 I V A A L D G T F Q R K P F G
Dog Lupus familis XP_540462 242 26432 T127 I V A A L D G T F Q R K A F G
Cat Felis silvestris
Mouse Mus musculus P04184 233 25757 T127 I V A A L D G T F Q R K A F G
Rat Rattus norvegicus P27158 121 13492 V40 S T E L M R R V R R F Q I A Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521037 255 27396 T149 I V A A L D G T F Q R K A F G
Chicken Gallus gallus P04047 224 24853 T128 I V A A L D G T F Q R K A F G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_956126 230 25567 T128 I V A A L D G T F Q R K A F G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784788 227 25150 T120 I V A A L D G T Y Q R K G F G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.7 98.7 89.2 N.A. 87.1 47 N.A. 72.9 73 N.A. 65.8 N.A. N.A. N.A. N.A. 48.7
Protein Similarity: 100 75.7 99.1 90.9 N.A. 91.8 50 N.A. 78 82 N.A. 74.7 N.A. N.A. N.A. N.A. 62.8
P-Site Identity: 100 100 100 93.3 N.A. 93.3 0 N.A. 93.3 93.3 N.A. 93.3 N.A. N.A. N.A. N.A. 86.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 20 N.A. 93.3 93.3 N.A. 93.3 N.A. N.A. N.A. N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 90 90 0 0 0 0 0 0 0 0 50 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 90 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 80 0 10 0 0 90 0 % F
% Gly: 0 0 0 0 0 0 90 0 0 0 0 0 10 0 90 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 90 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 90 0 0 0 % K
% Leu: 0 0 0 10 90 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 30 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 90 0 10 0 0 10 % Q
% Arg: 0 0 0 0 0 10 10 0 10 10 90 0 0 0 0 % R
% Ser: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 10 0 0 0 0 0 90 0 0 0 0 0 0 0 % T
% Val: 0 90 0 0 0 0 0 10 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _